Cone myoid elongation involves unidirectional microtubule movement mediated by dynein-1
نویسندگان
چکیده
منابع مشابه
Microtubules in cone myoid elongation in the teleost retina
The myoids of retinal cone cells of the blue-striped grunt (Haemulon sciurus) undergo significant elongation during dark adaptation of the retina. Longitudinally oriented microtubules are present in myoids both before and after elongation. Injection of colchicine into the vitreous of the eye in vivo disrupts the microtubules in the myoids and prevents dark-adaptive myoid elongation. Counts of m...
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The host cell microfilaments and microtubules (MTs) are known to play a critical role in the life cycles of several pathogenic intracellular microbes by providing for successful invasion and promoting movement of the pathogen once inside the host cell cytoplasm. Orientia tsutsugamushi, an obligate intracellular bacterium, enters host cells by induced phagocytosis, escapes to the cytosol, and th...
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A model for the unidirectional movement of dynein is presented based on the structural observations and biochemical experimental results available. In this model, the binding affinity of dynein for microtubule (MT) is independent of its nucleotide state and the change between strong and weak MT-binding is determined naturally by the variation of relative orientation between the stalk and MT, as...
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Nuclear movement often requires interactions between the cell cortex and microtubules. A new study has revealed a novel protein interaction linking microtubule plus-ends with the cortex and a role for dynein in microtubule shrinkage-coupled movement.
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OBJECTIVE Macrophage survival and proliferation is believed to be a contributing factor in the development of early atherosclerotic lesions. Oxidized low density lipoprotein (oxLDL), a key mediator in the pathogenesis of this disease, has been shown to block apoptosis in macrophages deprived of growth factor. In this report, we investigate the mechanism of oxLDL-mediated macrophage survival. ...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2018
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e17-08-0525